DJ-1 Protects Human Retinal Endothelial Cells From Diabetes-Related Conditions and Prevents Ischemic Damage in Mouse Retinal Capillaries
The results suggest that DJ-1 protects retinal capillary endothelial cells from damage caused by hyperglycemia and ischemia and that enhancing DJ-1 activity could be a strategy for mitigating early retinal damage in DR.
Authors
- Ram H. Nagaraj (ORCID: https://orcid.org/0000-0003-4737-8847)
- Sudipta Panja (ORCID: https://orcid.org/0000-0001-8413-2913)
- Mi‐Hyun Nam
- Jung Soo Suk (ORCID: https://orcid.org/0000-0002-2437-0001)
- Yang Shan (ORCID: https://orcid.org/0000-0002-0639-4501)
- Patrice E. Fort (ORCID: https://orcid.org/0000-0003-3956-1908)
- Rooban B. Nahomi (ORCID: https://orcid.org/0000-0001-7702-3225)
- W. Clay Smith (ORCID: https://orcid.org/0000-0002-6644-0231)
Institutions
- University of Michigan (US)
- University of Florida (US)
- Michigan United (US)
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1167/iovs.66.14.8
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Research to Prevent Blindness
- Bill and Melinda Gates Institute for Population and Reproductive Health