GLP-1 receptor agonists and coronary plaques regression in diabetic patients after acute coronary syndromes
In diabetic patients with ACS, GLP-1Ra therapy was associated with a significant regression in coronary plaque burden at 1 year, supported by favorable lipidomic, metabolomic, and proteomic changes. These findings suggest a potential role for GLP-1Ra in modifying atherosclerosis progression beyond glycemic control.
Authors
- Davide Cao (ORCID: https://orcid.org/0000-0001-7755-4069)
- Carlo Andrea Pivato (ORCID: https://orcid.org/0000-0001-5195-8815)
- Gianluca Mincione
- Paolo Fiorina (ORCID: https://orcid.org/0000-0002-1093-7724)
- Roberta Maria Fiorina
- Mauro Gitto (ORCID: https://orcid.org/0000-0002-4936-3860)
- Marco Francone (ORCID: https://orcid.org/0000-0002-7906-3420)
- Loredana Bucciarelli (ORCID: https://orcid.org/0000-0001-9110-6529)
- Alessandra Petrelli (ORCID: https://orcid.org/0000-0002-5639-9415)
- Damiano Regazzoli (ORCID: https://orcid.org/0000-0003-3845-9178)
- Giulio Stefanini (ORCID: https://orcid.org/0000-0002-3558-6967)
- Federica Catapano (ORCID: https://orcid.org/0000-0002-1004-5451)
- Cristian Loretelli (ORCID: https://orcid.org/0000-0002-7583-8540)
- Vincenzo Scialò
- Gianluigi Condorelli
- Costanza Lisi
Institutions
- Boston Children's Hospital (US)
- Humanitas University (IT)
- Harvard University (US)
- University of Milan (IT)
- ASST Fatebenefratelli Sacco (IT)
- IRCCS Humanitas Research Hospital (IT)
Publication Details
- Journal
- Acta Diabetologica
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1007/s00592-025-02606-z
- Citations
- 4
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 5.18