Emergence of co-resistance to imipenem/relebactam and ceftazidime/avibactam in clinical <i>Klebsiella pneumoniae</i> ST11 clone due to KPC-2 N132S and CTX-M-65 S130G/P167S substitutions
Two episodes of imipenem/relebactam and ceftazidime/avibactam co-resistant <i>Klebsiella pneumoniae</i> infections were identified in a Chinese hospital with an 8-month interval. All strains belonged to the ST11-KL64 clone, with pairwise SNP distances ranging from 1 to 9, indicating clonal spread. Plasmid-borne <i>bla</i><sub>KPC-157</sub> (KPC-2 N132S substitution) and <i>bla</i><sub>CTX-M-249</sub> (CTX-M-65 S130G/P167S substitutions) conferred resistance to imipenem/relebactam and ceftazidime/avibactam, respectively. The emergence of these novel resistance determinants in the high-risk clone underscores the need for enhanced surveillance.
Authors
- Min Xu (ORCID: https://orcid.org/0000-0002-8804-0431)
- Jiahong Xie (ORCID: https://orcid.org/0000-0001-8622-7289)
- Wei Chen (ORCID: https://orcid.org/0000-0002-2373-2437)
- Yuchao Zhang (ORCID: https://orcid.org/0000-0002-8289-3003)
- Jun Zhao (ORCID: https://orcid.org/0000-0002-7964-9739)
- Yiqi Fu (ORCID: https://orcid.org/0000-0001-8134-7994)
- Tingting Yang (ORCID: https://orcid.org/0000-0002-4181-1171)
- Haishen Kong
Institutions
- Zhejiang Medical and Health Group Hangzhou Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Antimicrobial Agents and Chemotherapy
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1128/aac.00891-25
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59