Mesenchymal stem-derived exosomes enhance therapeutic benefits of exercise in isoproterenol-induced myocardial ischemia: Targeting ERK and Akt/mTOR signaling
Functional and structural cardiac improvements are accompanied by reduced inflammation, oxidative stress, and apoptosis. Both MSC-EXO and EXE exert cardio-protection by upregulating sarcoplasmic endoplasmic reticulum calcium ATPase, the critical pump for normal calcium handling.
Authors
- Asmaa Selmy
- Dina Helmy Abdel-Kader
- Samar H. Elsharkawy (ORCID: https://orcid.org/0000-0002-9496-6601)
- Asmaa Mohammed ShamsEldeen (ORCID: https://orcid.org/0000-0002-4250-0818)
- N. Mohamed
- Samaa Samir Kamar (ORCID: https://orcid.org/0000-0002-9040-584X)
- Salwa Faisal (ORCID: https://orcid.org/0000-0002-0821-3487)
- W. Osman (ORCID: https://orcid.org/0000-0001-8060-4469)
- Laila A. Rashed (ORCID: https://orcid.org/0000-0001-8534-7174)
- Marwa Abdel-Rahman (ORCID: https://orcid.org/0000-0003-1035-5676)
- Manar M AbdElalim
Institutions
- Suez Canal University (EG)
- Cairo University (EG)
- Al-Azhar University (EG)
- Research Institute of Ophthalmology (EG)
- Armed Forces College of Medicine (EG)
Publication Details
- Journal
- World Journal of Stem Cells
- Published
- 2025-10-24
- DOI
- https://doi.org/10.4252/wjsc.v17.i10.109862
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81