Cellular profiling identifies targetable T cell phenotypes in lymphocytic variant hypereosinophilic syndrome
With cell-by-cell mapping, we charted immune cells in lymphocytic-variant hypereosinophilic syndrome, found drug targets, and showed targeted therapy removed disease-causing cells and eased symptoms.
Authors
- Spencer Ng (ORCID: https://orcid.org/0000-0002-1251-4514)
- Jaehyuk Choi (ORCID: https://orcid.org/0000-0003-2379-2226)
- Arundhati Pillai (ORCID: https://orcid.org/0000-0002-7234-8255)
- Jeffrey B. Cheng (ORCID: https://orcid.org/0000-0001-9821-4549)
- Raymond J. Cho (ORCID: https://orcid.org/0000-0001-6090-6603)
- Kristy Tefft (ORCID: https://orcid.org/0000-0003-2439-5927)
- Fei Kuang (ORCID: https://orcid.org/0000-0001-6384-2334)
- Brett King (ORCID: https://orcid.org/0000-0002-4576-4616)
- Zachary Z. Reinstein (ORCID: https://orcid.org/0000-0003-3310-0262)
- Yue Zhang (ORCID: https://orcid.org/0000-0002-3148-8833)
- Amy Wang (ORCID: https://orcid.org/0009-0004-6846-786X)
- Sung‐Hee Hwang
Institutions
- Northwestern University (US)
- University of California, San Francisco (US)
- San Francisco VA Health Care System (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Journal of Clinical Investigation
- Published
- 2025-11-02
- DOI
- https://doi.org/10.1172/jci190853
- Primary Topic
- Eosinophilic Disorders and Syndromes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Office of Research and Development
- LEO Fondet
- National Institutes of Health