Sclerostin-silenced human umbilical cord mesenchymal stem cells ameliorate bone metabolism in steroid-induced femoral head necrosis
sh-hUCMSCs alleviate SANFH by activating the Wnt/β-catenin signaling pathway, thereby promoting osteogenic differentiation and suppressing adipogenesis to restore bone metabolic balance.
Authors
- Chuncheng Wei (ORCID: https://orcid.org/0000-0001-5230-467X)
- Shijin Lu (ORCID: https://orcid.org/0000-0003-2396-5510)
- Yijing Tao (ORCID: https://orcid.org/0000-0001-6266-6594)
- Chi Zheng (ORCID: https://orcid.org/0009-0005-0964-0156)
- Xingyu Chen (ORCID: https://orcid.org/0000-0001-5711-7996)
- He Lv (ORCID: https://orcid.org/0009-0002-0671-4197)
- Feng Lin (ORCID: https://orcid.org/0000-0002-2057-1834)
- Zhe Feng (ORCID: https://orcid.org/0000-0001-5625-1501)
Institutions
- Zhejiang Chinese Medical University (CN)
- Guangxi University (CN)
- Guangxi Zhuang Autonomous Region Health and Family Planning (CN)
- Guangxi University of Chinese Medicine (CN)
- Ruikang Affiliated Hospital of Guangxi Medical University (CN)
Publication Details
- Journal
- World Journal of Stem Cells
- Published
- 2025-10-24
- DOI
- https://doi.org/10.4252/wjsc.v17.i10.110190
- Citations
- 2
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.44