Efficacy of inhaled nebulised unfractionated heparin to prevent intubation or death in hospitalised patients with COVID-19: an investigator-initiated international meta-trial of randomised clinical studies
The Sponsor of the meta-trial was the INHALE-HEP Collaborative Research Group (CRG); investigators of each contributing study were members of the INHALE-HEP CRG. No funding was received for the meta-trial. The Brazilian study was funded by The J.R. Moulton Charity Trust. The Irish study was funded by a Grant from Science Foundation Ireland to Cúram, the SFI's Centre for Research in Medical Devices (Research Centre Award Reference: 13/RC/2073).
Authors
- Rabab S.S. Mahrous (ORCID: https://orcid.org/0000-0003-4609-5474)
- Frank M.P. van Haren (ORCID: https://orcid.org/0000-0001-8037-4229)
- Anusha Belani
- Aino Nindya Auerkari (ORCID: https://orcid.org/0000-0002-2701-8580)
- Ruben Barbera
- Marcus Josephus Schultz (ORCID: https://orcid.org/0000-0003-3969-7792)
- Thomas Smoot (ORCID: https://orcid.org/0000-0002-6188-2217)
- Khine Sann
- Adhrie Sugiarto (ORCID: https://orcid.org/0000-0003-2542-1373)
- Herikurniawan Herikurniawan (ORCID: https://orcid.org/0000-0003-4073-0596)
- Ashley Woodcock (ORCID: https://orcid.org/0000-0002-5428-8578)
- Antonio Artigas (ORCID: https://orcid.org/0000-0002-8029-1017)
- Catriona Cody
- Sabrina Staas
- David Cosgrave (ORCID: https://orcid.org/0000-0002-5069-0201)
- Carlos Sverdloff (ORCID: https://orcid.org/0000-0001-8676-5431)
- Sidharta Kusuma Manggala (ORCID: https://orcid.org/0000-0002-0974-5864)
- Gerard F. Curley (ORCID: https://orcid.org/0000-0003-0271-195X)
- Miles Carroll
- Barry Dixon (ORCID: https://orcid.org/0000-0002-5151-1674)
- Septian Adi Permana (ORCID: https://orcid.org/0000-0002-2535-0483)
- Dita Aditianingsih (ORCID: https://orcid.org/0000-0001-6201-2400)
- Mary Carroll (ORCID: https://orcid.org/0000-0001-5396-221X)
- Marta Camprubí–Rimblas (ORCID: https://orcid.org/0000-0002-4085-5324)
- Thomas S. Wilkinson (ORCID: https://orcid.org/0000-0003-0397-6079)
- Caitlin Sas
- Janis K. Shute (ORCID: https://orcid.org/0000-0002-6586-7583)
- Dave Singh (ORCID: https://orcid.org/0000-0001-8918-7075)
- Robert Sinto
- Christopher Hillman
- Gilberto De Nucci (ORCID: https://orcid.org/0000-0002-4346-7941)
- Mohamed Badr (ORCID: https://orcid.org/0000-0002-1301-3842)
- Clive Page (ORCID: https://orcid.org/0000-0002-9358-3799)
- Sarah J. Valle (ORCID: https://orcid.org/0000-0002-1696-2912)
- Alicia Vilaseca
- John G. Laffey (ORCID: https://orcid.org/0000-0002-1246-9573)
- Ary Serpa Neto
- Mira Yulianti
- Tarek I. Ismail
Institutions
- Australian National University (AU)
- Royal College of Surgeons in Ireland (IE)
- Universidade de São Paulo (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- King's College London (GB)
- Ollscoil na Gaillimhe – University of Galway (IE)
- Mahidol University (TH)
- Calvert Memorial Hospital (US)
- Austin Hospital (AU)
- Connolly Hospital Blanchardstown (IE)
- Nuffield Orthopaedic Centre (GB)
- Beaumont Hospital (IE)
- University Hospital Galway (IE)
- University of Manchester (GB)
- University of Indonesia (ID)
- St Vincent's Hospital Melbourne (AU)
- Australian and New Zealand Intensive Care Society (AU)
- LinkGen (Brazil) (BR)
- NIHR Southampton Respiratory Biomedical Research Unit (GB)
- St George Hospital (AU)
- Mahidol Oxford Tropical Medicine Research Unit (TH)
- Institut Seni Indonesia Surakarta (ID)
- Institute of Research and Innovation Parc Tauli (ES)
- Medicines Evaluation Unit (GB)
- Amsterdam University Medical Centers (NL)
- Universitas Sahid Surakarta (ID)
- Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo (ID)
- University of Southampton (GB)
- Monash University (AU)
- University of Portsmouth (GB)
- Helwan University (EG)
- Alexandria University (EG)
Publication Details
- Journal
- EClinicalMedicine
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1016/j.eclinm.2025.103339
- Citations
- 2
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Science Foundation Ireland