IDR-driven LLPS of GAS2L3 scaffolds CHMP4B condensates to accelerate cytokinesis in hepatocellular carcinoma cells
GAS2L3 critically regulates cytokinesis in HCC through LLPS-mediated remodeling of midbody abscission microenvironment. These findings reveal novel insights into HCC hyperproliferation and suggest GAS2L3 as a potential therapeutic target.
Authors
- Lei Shi (ORCID: https://orcid.org/0000-0003-1679-3618)
- Peiying Li (ORCID: https://orcid.org/0000-0002-5721-9914)
- Zhi Yao (ORCID: https://orcid.org/0000-0001-8472-0731)
- Xingjie Gao (ORCID: https://orcid.org/0000-0002-3287-7697)
- Yuanyuan Ren (ORCID: https://orcid.org/0000-0001-6432-6876)
- Yan Zhao (ORCID: https://orcid.org/0000-0001-7474-3753)
- Jihui Hao (ORCID: https://orcid.org/0000-0002-1607-1730)
- Xing Cui (ORCID: https://orcid.org/0000-0002-8771-5898)
- Rui Chen (ORCID: https://orcid.org/0000-0002-3813-1749)
- Baoxin Qian (ORCID: https://orcid.org/0009-0007-6608-0073)
- Chunyan Zhao (ORCID: https://orcid.org/0009-0001-7071-1962)
- Chao Su (ORCID: https://orcid.org/0000-0002-1270-2064)
- Zheng Miao
- Jie Yang
Institutions
- Tianjin Medical University General Hospital (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Tianjin Medical University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.jare.2025.10.064
- Citations
- 1
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.82