Deracemization by coupling electrochemically assisted racemization and asymmetric crystallization
Amino acid derivatives of <i>tert</i>-leucine and phenyl glycine along with plant growth retardant and the precursor of fungicide paclobutrazol are deracemized by combining <i>in situ</i> electrochemical base generation to induce racemization and crystallization-induced chiral amplification in a one-pot, two-step deracemization procedure. Full enantioselective conversion (e.e. > 99%) of a mixture of enantiomers towards the desired handedness is achieved.
Authors
- Richard M. Kellogg (ORCID: https://orcid.org/0000-0002-8409-829X)
- Sjoerd W. van Dongen (ORCID: https://orcid.org/0000-0003-3617-5614)
- Anne-Sophie Léonard
- Roberta Listro (ORCID: https://orcid.org/0000-0001-7615-1284)
- Susanna Bertuletti (ORCID: https://orcid.org/0000-0002-8231-3566)
- Michel Leeman (ORCID: https://orcid.org/0000-0002-8854-1084)
- Timothy Noël (ORCID: https://orcid.org/0000-0002-3107-6927)
- Willem L. Noorduin (ORCID: https://orcid.org/0000-0003-0028-2354)
- Morgan Regnier (ORCID: https://orcid.org/0000-0003-0946-1084)
Institutions
- University of Pavia (IT)
- Institute for Atomic and Molecular Physics (NL)
- Dialyse Centrum Groningen (NL)
- Flevoziekenhuis (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc05874k
- Primary Topic
- Origins and Evolution of Life
- Type
- article
- Field-Weighted Citation Impact
- 0.00