Vitreous STMN2 levels reflect TDP-43-associated neurodegeneration in postmortem eyes and brains
Stathmin-2 (STMN2) levels decline in brains with transactive response DNA binding protein-43 (TDP-43) inclusions. TDP-43-related changes could extend to ocular structures, although vitreous STMN2 levels remain uncharacterized. This exploratory study analyzed 72 post-mortem brains and eyes depending on the presence or absence of TDP-43 inclusions in the brain and across neuropathological diagnostic groups (Alzheimer's disease [AD], chronic traumatic encephalopathy [CTE], AD and CTE, or neither). Results showed decreased vitreous STMN2 levels in TDP-43-positive cases but no association with diagnostic groups. Vitreous STMN2 was correlated with vitreous neurofilament light chain. Diminished vitreous STMN2 levels might indicate TDP-43-associated neurodegeneration.
Authors
- Raymond Nicks
- Surya Pulukuri (ORCID: https://orcid.org/0000-0002-0751-0201)
- Thor D. Stein (ORCID: https://orcid.org/0000-0001-6954-4477)
- Ann C. McKee (ORCID: https://orcid.org/0000-0003-2961-7488)
- Manju L. Subramanian (ORCID: https://orcid.org/0000-0002-0061-098X)
- Konstantina Sampani (ORCID: https://orcid.org/0000-0002-6570-328X)
- Fatima Tuz‐Zahra (ORCID: https://orcid.org/0000-0003-1763-255X)
- Daniel A. Mordes
- Weiming Xia (ORCID: https://orcid.org/0000-0002-7463-3295)
- Elizabeth Spurlock (ORCID: https://orcid.org/0000-0002-7781-7962)
- Yorghos Tripodis (ORCID: https://orcid.org/0000-0003-2190-7608)
- Gaoyuan Meng (ORCID: https://orcid.org/0000-0002-2318-9374)
- Victor E. Alvarez
Institutions
- Boston University (US)
- Boston Medical Center (US)
- Joslin Diabetes Center (US)
- Harvard University (US)
- University of California, San Francisco (US)
- VA Boston Healthcare System (US)
- University of California System (US)
- VA New England Healthcare System (US)
- Geriatric Research Education and Clinical Center (US)
- Institute for Neurodegenerative Disorders (US)
Publication Details
- Journal
- Journal of Alzheimer s Disease Reports
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1177/25424823251392553
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00