CircPPP1CB subtype, hsa_circ_0007439, promotes nasopharyngeal carcinoma progression by upregulating KRT1
This study is the first to demonstrate that hsa_circ_0007439 functions as a competitive endogenous RNA to upregulate KRT1 expression, thereby promoting the metastasis of NPC, suggesting that hsa_circ_0007439 serve as a potential diagnostic biomarker and therapeutic target for NPC.
Authors
- Ting Xu (ORCID: https://orcid.org/0000-0001-6123-9814)
- Qi Wang (ORCID: https://orcid.org/0009-0007-4340-6827)
- Qiqi Guo (ORCID: https://orcid.org/0000-0001-8756-4279)
- Jane Fan
- Qing Zhang (ORCID: https://orcid.org/0000-0001-7941-4318)
- Qian Yang (ORCID: https://orcid.org/0000-0001-8929-6765)
- Chunmou Li (ORCID: https://orcid.org/0000-0001-8279-5115)
- Jin‐Fei Lin
- Haisheng Chen (ORCID: https://orcid.org/0000-0002-1383-9476)
- Xuan Huang (ORCID: https://orcid.org/0000-0002-9708-2270)
- Maozhen Zeng
- Junru Chen (ORCID: https://orcid.org/0000-0003-4553-6979)
- Yue He (ORCID: https://orcid.org/0000-0002-5764-8866)
- Fei Li (ORCID: https://orcid.org/0009-0003-8992-2844)
- Jiasheng Wang (ORCID: https://orcid.org/0000-0003-0695-0800)
- Jian Cao (ORCID: https://orcid.org/0000-0003-4132-5939)
- Rui Sun (ORCID: https://orcid.org/0000-0002-8484-8089)
- Wenjing Cai (ORCID: https://orcid.org/0000-0003-3894-9708)
- Peiling Chen (ORCID: https://orcid.org/0000-0003-0636-3032)
Institutions
- Sun Yat-sen University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Key Laboratory of Guangdong Province (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1007/s12672-025-03888-z
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00