Stepwise dose reduction and discontinuation of bDMARD in rheumatoid arthritis: a prospective cohort study of flare-free population, flares, and predictive markers
Tapering bDMARD may maintain disease control short-term, but discontinuation increases flare risk. Ultrasound findings and ACPA-positivity are valuable predictors, and concomitant methotrexate use may help prevent flares after discontinuation.
Authors
- Koji Kinoshita (ORCID: https://orcid.org/0000-0003-1809-5143)
- Chisato Ashida (ORCID: https://orcid.org/0000-0003-3137-0138)
- Toshihiko Shiga (ORCID: https://orcid.org/0009-0008-3110-4976)
- Daisuke Tomita (ORCID: https://orcid.org/0000-0001-9762-5055)
- Yuji Nozaki (ORCID: https://orcid.org/0000-0003-2810-1519)
- Tetsu Itami (ORCID: https://orcid.org/0009-0000-9991-4176)
- Yumi Morimoto
- Rika Fukuda
- Kazuya Kishimoto
- Kaori Ishimura
- Hirotaka Yamazawa (ORCID: https://orcid.org/0009-0000-1525-9347)
Institutions
- Kindai University Hospital (JP)
- Kindai University (JP)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1186/s13075-025-03672-y
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00