TBAI-catalyzed C–H bond activation to construct the C <sub>(sp3)</sub> –O bond in water: synthesis of indole-3-carboxylic-α-esters under metal-free conditions
An environmentally friendly and green transition-metal-free TBAI-catalyzed C-O coupling reaction mediated by C<sub>(sp3)</sub>-H activation was developed to construct indole-3-carboxylic-α-esters in water. This reaction exhibited a broad substrate scope and good functional group tolerance. Remarkably, a gram-scale reaction and late-stage functionalization of many carboxylic acid drugs were smoothly achieved under the mild conditions.
Authors
- Xiaofeng Zhu (ORCID: https://orcid.org/0000-0003-0154-3317)
- Xinyuan Zhang (ORCID: https://orcid.org/0000-0002-4636-1202)
- Lingkai Kong (ORCID: https://orcid.org/0000-0003-4162-2837)
- Sishen Xie (ORCID: https://orcid.org/0000-0002-3737-6162)
- N.-L. Wang
- Chengyu Wang (ORCID: https://orcid.org/0000-0002-9238-6582)
- Yufang Sun
- Fuchun Yang
- Yuan Qu (ORCID: https://orcid.org/0000-0001-8423-3976)
- Jiawen Du (ORCID: https://orcid.org/0000-0003-3711-8101)
Institutions
- Linyi University (CN)
- Peking University (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob01449b
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00