A molecular convergence in the triad of parkinson’s disease, depressive disorder and gut health is revealed by the inflammation-miRNA axis
This study identifies a specific inflammation-miRNA pathway as a common molecular mechanism connecting the pathophysiology of PD, DD, and gut dysfunction. This pattern represents a critical point of convergence that drives a shared, bidirectional inflammatory cascade along the gut-brain axis. Targeting this miRNA triad could provide a new therapeutic approach for addressing the motor, psychiatric, and GI symptoms of these interconnected disorders simultaneously.
Authors
- J. Javier Meana (ORCID: https://orcid.org/0000-0002-7913-6714)
- Lluís Miquel-Rio (ORCID: https://orcid.org/0000-0002-3547-6004)
- Analı́a Bortolozzi (ORCID: https://orcid.org/0000-0002-2069-9192)
- Luís F. Callado (ORCID: https://orcid.org/0000-0001-9941-012X)
- Verónica Paz (ORCID: https://orcid.org/0000-0002-3225-7295)
- Unai Sarriés-Serrano (ORCID: https://orcid.org/0000-0002-7960-2738)
- Judith Jericó-Escolar
- Claudia Yanes-Castilla (ORCID: https://orcid.org/0009-0008-5635-1965)
Institutions
- Universitat Autònoma de Barcelona (ES)
- University of the Basque Country (ES)
- Instituto de Salud Carlos III (ES)
- BioCruces Health research Institute (ES)
- Institut d'Investigacions Biomèdiques de Barcelona (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Medical Research Network (US)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1186/s12974-025-03608-y
- Citations
- 1
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.58
Funders
- Fundació la Marató de TV3
- Ministerio de Ciencia, Innovación y Universidades
- Generalitat de Catalunya
- Eusko Jaurlaritza
- Universitat de Barcelona
- Centro de Investigación Biomédica en Red de Salud Mental
- Universitat Autònoma de Barcelona
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- Agencia Estatal de Investigación