Sepsis Circulating Extracellular Vesicles: Associated Cytokine Profile, Cellular Proliferation, and Cytoprotective Activity Against Lipopolysaccharide-Induced Cytotoxicity
These findings indicate that the enrichment of IL-15, IL-10 and G-CSF in sepsis circulating EVs represents a biologically active protein signature with potential to both modulate the immune response and serve as a novel diagnostic biomarker.
Authors
- Carola U. Niesler (ORCID: https://orcid.org/0000-0003-1782-130X)
- Irene Mackraj (ORCID: https://orcid.org/0000-0002-7488-3091)
- Usri H. Ibrahim (ORCID: https://orcid.org/0000-0002-3921-7616)
- Roushka Bhagwan Valjee (ORCID: https://orcid.org/0000-0002-8874-0040)
- Kwanele Xulu (ORCID: https://orcid.org/0000-0002-1115-0640)
Institutions
- Umkhuseli Innovation and Research Management (ZA)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- Immunological Investigations
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1080/08820139.2025.2572521
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00