RANBP1 promotes immune evasion in triple-negative breast cancer by suppressing T cell infiltration via the miR-769-5p/PRUNE2 axis
RANBP1 shapes an immunosuppressive microenvironment in TNBC by reducing T cell infiltration through the miR-769-5p/PRUNE2 axis. These findings reveal a novel immune escape mechanism and suggest that targeting RANBP1 may enhance immunotherapy efficacy in TNBC.
Authors
- Meng Cao
- Yanhui Cao (ORCID: https://orcid.org/0000-0001-6961-3559)
- Huiping Qiu
- Xin Zheng (ORCID: https://orcid.org/0000-0003-1414-1755)
- Shuihong Yao (ORCID: https://orcid.org/0000-0001-8963-2263)
- Jie Liu (ORCID: https://orcid.org/0000-0003-1398-5411)
- Xianglin Liu (ORCID: https://orcid.org/0000-0002-6742-7768)
- Pengxia Song
Institutions
- Quzhou College of Technology (CN)
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1007/s12672-025-03872-7
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nanjing Medical Science and Technique Development Foundation