Prevalence and clinical significance of the rare HOXB13 X285K variant in a French Caribbean prostate cancer cohort
Although limited by small sample size, these findings suggest a possible link between the HOXB13 X285K variant and early tumor progression. This highlights the importance of screening for this rare variant, particularly in patients of African descent who are underrepresented in genomic studies, to support improved risk stratification and personalized management.
Authors
- Mickaelle Rose
- Nathalie Leclerc (ORCID: https://orcid.org/0000-0001-9050-8753)
- Mylène Annonay (ORCID: https://orcid.org/0000-0002-1639-8661)
- Alicia Martín Martínez (ORCID: https://orcid.org/0000-0002-4237-6378)
- Sylvie Merle
- M. Percot
- Régine Marlin (ORCID: https://orcid.org/0000-0001-7580-2997)
- Xavier Promeyrat
- Catherine Ledoux
- Émeline Colomba (ORCID: https://orcid.org/0000-0002-3631-316X)
- Georges Comlan
- Alexis Vallard (ORCID: https://orcid.org/0000-0002-8147-1298)
- Donavine Nimubona
- Jean-Samuel Loger
- Odile Béra
- Sarah Malsa
- Norelyakin Kara
- Céline Minchaca
- Johan Rose-Dite-Modestine
- Eléna Lihiouel
- Laurianne Noly
Institutions
- Centre Hospitalier Universitaire de Martinique (MQ)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1186/s12885-025-15155-z
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00