Signaling pathway of DNA replication and toll-like receptors was inhibited in C6/36 cells infected with Japanese encephalitis virus
Our results suggest that JEV infection impairs DNA replication and innate immune responses, particularly the inhibition of PRI2 and POLε3, leading to increased JEV replication and potentially a key mechanism of JEV pathogenesis. Elucidating the interactions between JEV and the host DNA replication and immune system will facilitate the development of more effective JEV prevention and treatment strategies.
Authors
- Junduo Bao
- Huijun Lu (ORCID: https://orcid.org/0000-0003-4532-4466)
- Zhuoxin Li (ORCID: https://orcid.org/0000-0002-4687-4913)
- Xu Gao (ORCID: https://orcid.org/0000-0001-6334-3228)
- Xiangshu Qiu
- Jiaqi Zhang (ORCID: https://orcid.org/0000-0002-2885-3449)
- Bing Li (ORCID: https://orcid.org/0000-0002-9838-5871)
- Yan Gao (ORCID: https://orcid.org/0000-0003-0305-3696)
- Ning Shi (ORCID: https://orcid.org/0000-0002-8149-0210)
- Xinxin Shi (ORCID: https://orcid.org/0009-0006-2003-6635)
- Guanyu Zhao (ORCID: https://orcid.org/0000-0003-0787-9567)
- He Zhang (ORCID: https://orcid.org/0009-0001-1899-2402)
Institutions
- Yanbian University (CN)
- Changchun Institute of Applied Chemistry (CN)
- Jilin Academy of Agricultural Sciences (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Jilin Agricultural University (CN)
- Institute of Special Animal and Plant Sciences (CN)
- Zhejiang University (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1186/s12985-025-02956-8
- Citations
- 1
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Chinese Academy of Agricultural Sciences
- National Key Research and Development Program of China