Clinical analysis of Pneumocystis jirovecii pneumonia in children with malignant disease
High clinical suspicion for PJP is warranted in pediatric malignancy patients presenting with fever, dyspnea, elevated BDG, and characteristic imaging findings, particularly in those with inadequate prophylaxis. Early pathogen detection and treatment initiation are crucial. While TMP/SMZ remains first-line therapy, combination with caspofungin may improve outcomes. Short-term adjunctive corticosteroids may benefit moderate to severe cases.
Authors
- Jiaotian Huang
- Haixia Yang (ORCID: https://orcid.org/0000-0002-4410-9257)
- Shan He (ORCID: https://orcid.org/0000-0003-4032-1856)
- Wenyong Kuang
- Qiuxia Fan (ORCID: https://orcid.org/0000-0001-6132-5229)
- Haiyan Luo (ORCID: https://orcid.org/0000-0001-7120-5175)
- Zhang Ben-shan
- Xiaoming Li (ORCID: https://orcid.org/0000-0002-3059-0449)
- Wanli Li (ORCID: https://orcid.org/0000-0003-0271-5782)
- Xinping Zhang
- Mincui Zheng
- Pan Wu (ORCID: https://orcid.org/0009-0008-2174-2886)
Institutions
- Central South University (CN)
- Hunan Children's Hospital (CN)
Publication Details
- Journal
- BMC Pediatrics
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1186/s12887-025-06288-y
- Citations
- 1
- Primary Topic
- Pneumocystis jirovecii pneumonia detection and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35