Temporal evolution of large language models (LLMs) in oncology
Our meta-analysis reveals temporal performance degradation in ChatGPT-3.5 and ChatGPT-4, which contrasts with the consistent improvement observed in Gemini. These findings provide essential guidance for the evidence-based deployment of LLMs in oncology.
Authors
- Jason Chia‐Hsien Cheng (ORCID: https://orcid.org/0000-0002-2007-0220)
- Shengkun Peng
- Bufu Tang (ORCID: https://orcid.org/0000-0003-3525-4433)
- Wenyi Gan (ORCID: https://orcid.org/0000-0003-1886-8062)
- Dongqiang Zeng (ORCID: https://orcid.org/0000-0001-9724-8325)
- Lingxuan Zhu
- Hengguo Zhang (ORCID: https://orcid.org/0000-0002-4438-8348)
- Xinpei Deng (ORCID: https://orcid.org/0000-0001-9973-2559)
- Aimin Jiang (ORCID: https://orcid.org/0000-0002-9181-934X)
- Hank Z. H. Wong
- Peng Luo (ORCID: https://orcid.org/0000-0002-8215-2045)
- Mingjia Xiao
- Weiming Mou (ORCID: https://orcid.org/0009-0007-1089-6516)
- Lin Zhang (ORCID: https://orcid.org/0000-0003-0526-9677)
- Guangdi Chu (ORCID: https://orcid.org/0000-0002-2963-1741)
- Yaxuan Wang
- Jian Zhang (ORCID: https://orcid.org/0000-0001-7181-6021)
- Qi Chang (ORCID: https://orcid.org/0000-0001-6200-1111)
- Anqi Lin (ORCID: https://orcid.org/0000-0002-8352-8219)
- Zhiquan Qiu (ORCID: https://orcid.org/0009-0003-8383-2776)
Institutions
- Qingdao University (CN)
- Central South University (CN)
- University of Electronic Science and Technology of China (CN)
- Harbin Medical University (CN)
- Sun Yat-sen University (CN)
- Second Military Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Anhui Medical University (CN)
- Fudan University (CN)
- Quzhou City People's Hospital (CN)
- Nanfang Hospital (CN)
- Zhuhai People's Hospital (CN)
- Changhai Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Zhujiang Hospital (CN)
- Monash Health (AU)
- Quzhou University (CN)
- Suzhou Research Institute (CN)
- Zhongshan Hospital (CN)
- Shanghai First People's Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
- Xiangya Hospital Central South University (CN)
- Monash University (AU)
- Southern Medical University (CN)
- University of Hong Kong (HK)
- South China University of Technology (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1186/s12967-025-07227-2
- Citations
- 2
- Primary Topic
- Artificial Intelligence in Healthcare and Education
- Type
- article
- Field-Weighted Citation Impact
- 1.31