IL-5 signaling in asthmatic derived fibroblasts exacerbates airway remodeling through ECM dysregulation and apoptosis resistance
IL-5 directly activates lung fibroblasts to drive airway remodelling in severe asthma through ECM deposition, MMP/TIMP imbalance, and pro-fibrotic cytokine secretion, positioning it as a dual mediator of inflammation and fibrosis with novel therapeutic potential.
Authors
- Bushra Mdkhana (ORCID: https://orcid.org/0000-0003-0938-2239)
- Lina Sahnoon
- Qutayba Hamid (ORCID: https://orcid.org/0000-0002-1107-190X)
- Alaa Muayad Altaie (ORCID: https://orcid.org/0000-0002-2301-0899)
- Rifat Hamoudi (ORCID: https://orcid.org/0000-0002-1402-0868)
- Rola AbuJabal (ORCID: https://orcid.org/0009-0007-1367-9998)
- Yves Laumonnier (ORCID: https://orcid.org/0000-0001-9603-3269)
- Khuloud Bajbouj (ORCID: https://orcid.org/0000-0001-7344-6095)
- Bassam Mahboub (ORCID: https://orcid.org/0000-0002-6089-438X)
- Reem Sami Alhamidi (ORCID: https://orcid.org/0009-0006-2893-2872)
- Tasneem M. Alanta
Institutions
- Rashid Hospital (AE)
- University of Sharjah (AE)
- German Center for Lung Research (DE)
- Christie (Canada) (CA)
- University College London (GB)
- McGill University (CA)
- University of Pennsylvania (US)
- University of Lübeck (DE)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1186/s12931-025-03371-x
- Citations
- 1
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.16