The potential role of IgG subclass in NF155-associated nodopathy for targeting therapy: a pediatric case report highlighting the efficacy of pulsed oral corticosteroids
Pediatric patients presenting with demyelinating polyneuropathies unresponsive to intravenous immunoglobulins should be evaluated for autoimmune nodo-paranodopathies, including subclass-specific antibody profiling. In IgG1-NF155 associated autoimmune nodopathy, pulsed oral corticosteroids may represent an effective therapeutic option, whereas the response to intravenous immunoglobulin can be suboptimal.
Authors
- Egon Kurča (ORCID: https://orcid.org/0000-0002-1025-6830)
- Victor Mgbachi (ORCID: https://orcid.org/0000-0003-0826-4687)
- Simon Rinaldi (ORCID: https://orcid.org/0000-0003-2039-3457)
- Monika Turčanová Koprušáková (ORCID: https://orcid.org/0000-0002-7864-6560)
- E. Trusiková
Institutions
- John Radcliffe Hospital (GB)
- University of Oxford (GB)
- Akadémia Umení v Banskej Bystrici (SK)
- Martin University Hospital (SK)
- Comenius University Bratislava (SK)
Publication Details
- Journal
- BMC Neurology
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1186/s12883-025-04467-z
- Primary Topic
- Peripheral Neuropathies and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00