Single-cell multi-omics analysis revealed the expansion of age-associated B cells in the pancreas of type 1 autoimmune pancreatitis patients
These findings highlight significant alterations in the pancreatic immune microenvironment in AIP and propose a potential pathogenic model involving ABCs, Tfhs, and macrophages. This model provides valuable insights that could inform the development of targeted therapeutic strategies for AIP.
Authors
- Xiaonan Shen
- Xiangyi He
- Youqiong Ye (ORCID: https://orcid.org/0000-0001-8332-4710)
- Chenxiao Liu (ORCID: https://orcid.org/0000-0002-5349-2366)
- Yifei Chen (ORCID: https://orcid.org/0009-0005-5187-4642)
- Ling Zhang (ORCID: https://orcid.org/0000-0001-8371-5252)
- Xiang Ao (ORCID: https://orcid.org/0000-0001-8851-7706)
- Xian‐Da Zhang (ORCID: https://orcid.org/0009-0005-3705-7769)
- Chunhua Zhou (ORCID: https://orcid.org/0000-0003-1543-9000)
- Duowu Zou (ORCID: https://orcid.org/0000-0002-2461-5304)
- Jiaxin Wang (ORCID: https://orcid.org/0000-0001-6217-635X)
- Yao Zhang (ORCID: https://orcid.org/0000-0001-8878-891X)
- Dong Wang (ORCID: https://orcid.org/0000-0002-0594-0515)
- Li Wen (ORCID: https://orcid.org/0000-0002-2621-0239)
- Yanhua Du
- Qidi Yang (ORCID: https://orcid.org/0009-0007-9491-3909)
- Tingting Gong
- Yizhou Zhao (ORCID: https://orcid.org/0009-0009-9440-4324)
- Tianyi Che (ORCID: https://orcid.org/0009-0007-1402-9583)
- Minmin Zhang
- Xianzheng Qin
Institutions
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Ruijin Hospital (CN)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1186/s13073-025-01567-w
- Primary Topic
- IgG4-Related and Inflammatory Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality