Immunogenicity and gene polymorphism analysis of Plasmodium ovale wallikeri glycosylphosphatidylinositol-anchored micronemal antigen (GAMA)
This study illustrates the significant conservation of powgama gene sequences among P. ovale isolates. The rPowGAMA expressed from this conserved sequence demonstrates substantial immunogenicity, eliciting both high-avidity antibodies and robust T-cell responses. These findings indicate the potential of rPowGAMA to elicit dual protective immunity.
Authors
- Yifan Sun (ORCID: https://orcid.org/0000-0003-3060-1539)
- Qiubo Wang (ORCID: https://orcid.org/0000-0002-4974-791X)
- Yang Cheng (ORCID: https://orcid.org/0000-0002-3014-342X)
- Su Han (ORCID: https://orcid.org/0000-0002-9693-331X)
- Feng Chen (ORCID: https://orcid.org/0000-0003-4402-4955)
- Yuanqiang Tan (ORCID: https://orcid.org/0000-0002-3277-7506)
- Sui Xu
- Ling Xin (ORCID: https://orcid.org/0000-0001-9986-4551)
Institutions
- Jiangnan University (CN)
- Nantong University (CN)
- Soochow University (CN)
- Jiangsu Institute of Parasitic Diseases (CN)
- Nantong Science and Technology Bureau (CN)
- Hainan Center for Disease Control & Prevention (CN)
- Wuxi Ninth People's Hospital (CN)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1186/s12936-025-05603-3
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province