Endocrine effect of ghrelin on histological, hormonal and morphometric parameters of the pituitary gland and the possibility of its clinical application

This review showed that central administration of nanomolar doses of ghrelin in rats modulates the immunohistomorphometric and hormonal characteristics of pituitary hormone-producing cells. The changes are particularly significant in the volume of corticotropes, somatotropes, and luteinising hormone (LH)-producing cells, their volume density, and the levels of hormones they secrete, compared with the control group.