TRIB3 Links Endoplasmic Reticulum Stress to Impaired Efferocytosis in Atherosclerosis
Lipid-induced ER stress impairs macrophage efferocytosis via activation of the ATF4-TRIB3-Rab27a signaling axis, leading to exacerbated plaque necrosis. Targeted disruption of TRIB3 signaling in macrophages represents a novel therapeutic approach to promote efferocytosis and stabilize atherosclerotic plaques.
Authors
- Heather L. Wilson (ORCID: https://orcid.org/0000-0002-7892-3425)
- Carol C. Shoulders (ORCID: https://orcid.org/0000-0003-2218-1095)
- Patricia B. Munroe (ORCID: https://orcid.org/0000-0002-4176-2947)
- Eoin Brennan (ORCID: https://orcid.org/0000-0003-4908-5474)
- Thomas D. Nightingale (ORCID: https://orcid.org/0000-0002-3429-0988)
- Orina Belton (ORCID: https://orcid.org/0000-0002-7701-6540)
- Monica de Gaetano (ORCID: https://orcid.org/0000-0002-4677-1447)
- Stefan Russo (ORCID: https://orcid.org/0000-0002-2234-5515)
- Guillermo Velasco (ORCID: https://orcid.org/0000-0002-1994-2386)
- Umesh Kumar Dhawan (ORCID: https://orcid.org/0000-0002-2868-6361)
- Aarushi Singhal (ORCID: https://orcid.org/0000-0002-3973-4234)
- Endré Kiss-Toth (ORCID: https://orcid.org/0000-0003-4406-4017)
- Hedayatullah Hayat
- Mary Barry (ORCID: https://orcid.org/0000-0003-3780-5702)
- Manikandan Subramanian (ORCID: https://orcid.org/0000-0002-2608-3890)
- Catherine Godson (ORCID: https://orcid.org/0000-0003-0655-1041)
- Christopher G. Bell (ORCID: https://orcid.org/0000-0003-4601-1242)
- Kunzangla Bhutia
Institutions
- University College Dublin (IE)
- Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (ES)
- St. Vincent's University Hospital (IE)
- William Harvey Research Institute (GB)
- University of Sheffield (GB)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1161/circresaha.125.326839
- Citations
- 2
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.59