Intra-host diversity of SARS-CoV-2 in children with long-term and short-term excretion in nasopharyngeal samples
Our findings revealed significant intra-host variability in SARS-CoV-2 among severe and immunodeficient pediatric patients. These results underscore the critical importance of continuous surveillance of viral variants within pediatric populations to enhance our understanding of their impact on disease progression and clinical outcomes.
Authors
- Kaouther Ayouni (ORCID: https://orcid.org/0000-0002-0872-5706)
- Haifa Khemiri (ORCID: https://orcid.org/0009-0007-8556-7493)
- Najla Mekki (ORCID: https://orcid.org/0000-0002-5842-9147)
- Mohamed‐Ridha Barbouche (ORCID: https://orcid.org/0009-0009-4145-8644)
- Alessio Lorusso (ORCID: https://orcid.org/0000-0001-6156-8212)
- Henda Touzi
- Nicolas Radomski (ORCID: https://orcid.org/0000-0002-7480-4197)
- Monia Ouederni (ORCID: https://orcid.org/0000-0003-3642-6743)
- Adriano Di Pasquale (ORCID: https://orcid.org/0000-0002-9328-3972)
- Ilhem Ben Fraj (ORCID: https://orcid.org/0009-0008-2275-0896)
- H. Smaoui (ORCID: https://orcid.org/0000-0002-4026-0259)
- Mariem Gdoura (ORCID: https://orcid.org/0000-0002-2031-6534)
- Nahed Hogga
- Monia Ben Khaled (ORCID: https://orcid.org/0000-0003-3629-7515)
- Iolanda Mangone (ORCID: https://orcid.org/0000-0002-6716-091X)
- S. Rekaya
- Cesare Cammà
- S Boubaker (ORCID: https://orcid.org/0000-0001-9705-4387)
- Zina Meddeb
- Henda Triki
- Oussama Souiaï (ORCID: https://orcid.org/0000-0003-2443-114X)
- Amel Sadraoui
- Imen Ben‐Mustapha (ORCID: https://orcid.org/0000-0002-3526-2890)
- Khawla Meftah
Institutions
- Tunis University (TN)
- Institut Pasteur de Tunis (TN)
- Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale (IT)
- National Institute Of Blood Disease and Bone Marrow Transplantation (PK)
- Children's Hospital (TN)
- Arabian Gulf University (BH)
- Tunis El Manar University (TN)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1186/s12879-025-11759-9
- Primary Topic
- SARS-CoV-2 detection and testing
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute
- Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche