The molecular complexity of deep vein thrombosis was preliminarily explored based on the ceRNA network, scRNA-seq and AlphaFold 2
JAK2, CD36, TNFSF13B, TLR7 and PARP9 were identified as potential regulatory target genes for the pathophysiological process of DVT. Additionally, hsa_circ_0095124/hsa-miR-3074-5p/TNFSF13B is a potential regulatory pathway for DVT.
Authors
- Yang-yi-jing Wang
- Dong-yang Luo
- Qingyu Luo (ORCID: https://orcid.org/0000-0002-1980-4725)
- Zixuan Wu (ORCID: https://orcid.org/0000-0002-2993-9949)
- Guoshan Bi (ORCID: https://orcid.org/0000-0001-7661-6977)
- Liming Deng (ORCID: https://orcid.org/0000-0002-8862-9967)
- Xianpeng Dai (ORCID: https://orcid.org/0000-0001-9815-294X)
- Zhihe Deng
- Guozuo Xiong
- Mingjun Jiang (ORCID: https://orcid.org/0000-0002-4228-4916)
- Bin Pan (ORCID: https://orcid.org/0000-0001-9596-8871)
- Dongdong Ning (ORCID: https://orcid.org/0000-0001-8015-0831)
- Jie Chen (ORCID: https://orcid.org/0009-0003-2727-0289)
Institutions
- University of South China (CN)
Publication Details
- Journal
- BMC Medical Genomics
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1186/s12920-025-02239-9
- Primary Topic
- Venous Thromboembolism Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hunan Province
- University of South China
- Hunan Provincial Innovation Foundation for Postgraduate