Neighborhood deprivation, breast cancer outcomes and stress-related gene expression in leukocytes and tumor tissue
These findings suggest that neighborhood socioeconomic disadvantage may influence systemic immune regulation through stress-related transcriptional responses, which in turn contribute to tumor aggressiveness and survival disparities in breast cancer.
Authors
- Bernard F. Fuemmeler (ORCID: https://orcid.org/0000-0002-3550-0107)
- Hua Zhao (ORCID: https://orcid.org/0000-0002-1629-8695)
- Joseph Boyle (ORCID: https://orcid.org/0000-0002-1223-0191)
- Yufan Guan (ORCID: https://orcid.org/0009-0007-2579-0044)
- Jie Shen (ORCID: https://orcid.org/0000-0002-3845-2040)
Institutions
- Virginia Commonwealth University (US)
- University of Virginia (US)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1186/s13058-025-02146-y
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Cancer Institute