Genomic evolution of high-risk soft tissue sarcomas under thermo- and chemotherapeutic selection pressure
Our findings showcase the diversity of genomic evolution patterns in sarcomas emerging under combined thermo- and chemotherapeutic selection pressure, indicating that treatment response may vary according to the specific tumor composition. With previous studies linking histone functions to heat stress response, the alterations found in genes modifying H3 in our post-therapeutic cohort provide biological evidence for synergy of chemotherapy combined with regional hyperthermia in soft tissue sarcomas.
Authors
- David Kaul (ORCID: https://orcid.org/0000-0002-7906-5629)
- Bernhard Gillissen (ORCID: https://orcid.org/0000-0002-1815-2091)
- Daniel Rau (ORCID: https://orcid.org/0000-0002-4576-5707)
- Michael Hummel (ORCID: https://orcid.org/0000-0001-6717-605X)
- Eric Sträng (ORCID: https://orcid.org/0000-0001-6681-8735)
- Antje Richter
- Armin Jarosch (ORCID: https://orcid.org/0000-0002-6040-394X)
- Pirus Ghadjar (ORCID: https://orcid.org/0000-0002-2747-165X)
- Lars Bullinger (ORCID: https://orcid.org/0000-0002-5890-5510)
- Maximilian von Laffert (ORCID: https://orcid.org/0000-0002-8799-0427)
- Anna Dolnik (ORCID: https://orcid.org/0000-0003-4166-2900)
- Raphael Hablesreiter (ORCID: https://orcid.org/0000-0002-4586-932X)
- Jana K. Striefler (ORCID: https://orcid.org/0000-0002-0612-3023)
- Maren Schmiester (ORCID: https://orcid.org/0000-0002-8713-572X)
- Anne Flörcken
- Robert Öllinger (ORCID: https://orcid.org/0000-0002-4499-1673)
- Sven Märdian (ORCID: https://orcid.org/0000-0003-4220-2797)
- Antonia Freytag
Institutions
- Universität Hamburg (DE)
- University of Potsdam (DE)
- German Cancer Research Center (DE)
- University of Applied Sciences Potsdam (DE)
- Humboldt-Universität zu Berlin (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- University of Rostock (DE)
- Leipzig University (DE)
Publication Details
- Journal
- International Journal of Hyperthermia
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1080/02656736.2025.2573753
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00