Cannabidiol sensitizes triple-negative breast cancer cells to NK cell-mediated killing via EGFR inhibition and FAS upregulation
These findings suggest that CBD holds promise as a potential anticancer agent in TNBC by disrupting EGFR signaling and promoting apoptosis. However, further studies are necessary to optimize its therapeutic window and minimize adverse effects, particularly regarding its potential cytotoxicity to immune cells.
Authors
- Chairat Turbpaiboon (ORCID: https://orcid.org/0000-0001-9609-3034)
- Mutita Junking (ORCID: https://orcid.org/0000-0002-8347-3000)
- Krissada Natungnuy (ORCID: https://orcid.org/0009-0006-3754-6121)
- Boonyanuch Ramwarungkura
- Pa-thai Yenchitsomanus
- Perawat Garunyapakun
Institutions
- Siriraj Hospital (TH)
- Mahidol University (TH)
- Rangsit University (TH)
Publication Details
- Journal
- Journal of Cannabis Research
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1186/s42238-025-00340-5
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Mahidol University
- National Research Council of Thailand
- Rangsit University
- Faculty of Medicine Siriraj Hospital, Mahidol University