C1QTNF1-AS1/miR-346 axis suppresses osteosarcoma progression via dual inhibition of LDHA/PDK1-mediated Warburg effect
The C1QTNF1-AS1/miR-346 axis reveals a treatable vulnerability in OS metabolism. miR-346 is proposed as a first-class multitarget RNA therapy to weaken the Warburg effect, offering a novel strategy for metabolic intervention in OS.
Authors
- Keyue Ding (ORCID: https://orcid.org/0000-0002-3496-6415)
- Jingyi Hou (ORCID: https://orcid.org/0000-0003-0172-3115)
- Naiqiang Zhu (ORCID: https://orcid.org/0000-0002-9540-4408)
- Yu Zhang (ORCID: https://orcid.org/0000-0002-3702-6541)
- Yubo Li (ORCID: https://orcid.org/0000-0003-0455-0969)
- Ning Yang (ORCID: https://orcid.org/0000-0003-2071-3756)
- Bowen Xu (ORCID: https://orcid.org/0000-0001-5190-8324)
- Bin Chen (ORCID: https://orcid.org/0009-0000-9974-9430)
Institutions
- Chengde Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1186/s12885-025-14935-x
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Chengde Medical University