From crisis to recovery: life-saving IgM-enriched immunoglobulin rescue therapy in severe CAP and refractory post-partum septic shock – a dramatic 24-hour turnaround

IgM-enriched immunoglobulin therapy represents a viable adjunctive option for refractory sepsis, particularly in hyperinflammatory presentations. Early therapeutic intervention within 24 hours of refractory status may optimise clinical outcomes.Phenotype-based therapy selection can identify patients most likely to benefit from immunomodulatory interventions. Postpartum patients may experience worse outcome due to pregnancy-related immune modifications.Biomarker monitoring including procalcitonin and C-reactive protein can guide therapeutic decisions and evaluate treatment response.