When Parkinson's disease encounters high fever: two case reports and literature review

Parkinson's disease (PD) is a chronic progressive neurodegenerative disorder. Acute hyperthermia syndrome (AHS) associated with PD is a critical neurological condition requiring immediate intervention. This article presents two cases of patients with PD with hyperthermia and provides a comprehensive comparative analysis across multiple dimensions, including etiology, pathogenesis, clinical features, diagnostic approaches, therapeutic strategies, and outcomes. The first patient exhibited motor dysfunction followed by hyperthermia, which was alleviated by adjusting the dosage of dopaminergic medication. In contrast, the second patient was initially misdiagnosed with sepsis, and his condition significantly improved with dopaminergic therapy. This report aimed to enhance clinicians' understanding of this syndrome, improve diagnostic precision, and facilitate the development of more effective treatment protocols for optimizing patient outcomes.