Development of broadly neutralizing antibodies against Omicron variants from existing neutralizing antibodies in clinical trials
Together, our approach revealed the possibility of engineering of existing antibodies to broad-spectrum mAbs as potential therapeutic or prophylactic agents for COVID-19.
Authors
- Meng Ni (ORCID: https://orcid.org/0000-0002-5565-0639)
- Ling Sang (ORCID: https://orcid.org/0000-0001-5466-6834)
- Xiang Ling
- Zhihai Wu (ORCID: https://orcid.org/0000-0001-7293-9250)
- Zhiming Zhen (ORCID: https://orcid.org/0000-0001-6064-1916)
- Jincun Zhao
- Xi Yin (ORCID: https://orcid.org/0000-0002-7224-5272)
- Shuaixiang Zhou
- Yongbo Huang (ORCID: https://orcid.org/0000-0001-6798-0451)
- Mengzhu Zhu
- Yuheng Yu
- Ao Li (ORCID: https://orcid.org/0000-0002-7130-2386)
- Li Liu (ORCID: https://orcid.org/0000-0003-2566-7357)
- Fangfang Zhang (ORCID: https://orcid.org/0000-0002-6161-022X)
- Yiting Li (ORCID: https://orcid.org/0000-0001-8022-0203)
- Jianxing He (ORCID: https://orcid.org/0000-0003-1737-8192)
- Zhaoyong Zhang (ORCID: https://orcid.org/0000-0002-7322-7949)
- Yanqun Wang (ORCID: https://orcid.org/0000-0002-7056-2039)
- Zhimin Lin (ORCID: https://orcid.org/0009-0002-6034-1942)
- Jiantao Chen (ORCID: https://orcid.org/0000-0002-7214-2257)
- Xiaoqian Guo (ORCID: https://orcid.org/0009-0001-6018-2833)
- Wenhua Liang (ORCID: https://orcid.org/0000-0002-8159-7720)
Institutions
- Innovate UK (GB)
- Soochow University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1186/s12985-025-02964-8
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province