STC2+ Malignant Cell State Associated with EMT, Tumor Microenvironment Remodeling, and Poor Prognosis Revealed by Single-Cell and Spatial Transcriptomics in Colorectal Cancer
This study identified a malignant cell state in CRC that is metabolically defined and spatially limited, including liver metastases, and is characterized by elevated STC2 expression and active immune-stromal interactions. Given the interplay between metabolic reprogramming and TME remodeling, STC2+ malignant cells are a functionally significant subpopulation and a potential therapeutic target.
Authors
- Min Tang (ORCID: https://orcid.org/0000-0002-9738-8392)
- Wuxian Li
- Tianyi Yang (ORCID: https://orcid.org/0000-0001-5329-5867)
- Yue Wang (ORCID: https://orcid.org/0000-0001-6936-5081)
- Chengying Xiong
- Zhiqiang He (ORCID: https://orcid.org/0000-0001-8536-5970)
- Kai Gui (ORCID: https://orcid.org/0000-0003-1849-4830)
Institutions
- Chongqing Maternal and Child Health Hospital (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Published
- 2025-11-04
- DOI
- https://doi.org/10.32604/or.2025.070143
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00