Chemo‐Divergent Friedel–Crafts Alkylation and Friedel–Crafts Acylation of Arenes with <i>α</i> ‐Diazo Ketones Tuned by Reaction Conditions
A chemo‐divergent Friedel–Crafts alkylation and Friedel–Crafts acylation of arenes with α ‐diazo ketones has been developed. In this reaction, Cu(OTf) 2 catalyzed the Friedel–Crafts alkylation via Cu‐carbene intermediate, while hexafluoroisopropanol (HFIP) promoted the Friedel–Crafts acylation via the ketene intermediate. This protocol provides a controllable aromatic C(sp2)H bond functionalization of arenes by tuning the reaction conditions.
Authors
- Xinyu Huang
- Xinrong Zhi
- Lu Liu (ORCID: https://orcid.org/0000-0003-2151-891X)
- Xin Ji (ORCID: https://orcid.org/0000-0002-1410-3241)
Institutions
- East China Normal University (CN)
Publication Details
- Journal
- Chemistry - Methods
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1002/cmtd.202500108
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China