Longitudinal Circulating Tumor DNA Profiling as a Biomarker for Response and Resistance in Platinum-Refractory Head and Neck Squamous Cell Carcinoma
Serial ctDNA analysis provides a noninvasive tool for monitoring treatment response and detecting emerging resistance in HNSCC treated with ICIs. A significant reduction in ctDNA at 6 weeks was associated with improved clinical outcomes and warrants validation in larger, prospective studies to define its role as a predictive biomarker in HNSCC.
Authors
- Joo Yong Park (ORCID: https://orcid.org/0000-0002-0969-151X)
- Sung Weon Choi (ORCID: https://orcid.org/0000-0002-2038-2881)
- Chang Hwan Ryu (ORCID: https://orcid.org/0000-0001-8150-5163)
- Junsun Ryu (ORCID: https://orcid.org/0000-0002-6730-6755)
- Tak Yun (ORCID: https://orcid.org/0000-0001-9540-0397)
- Weon Seo Park (ORCID: https://orcid.org/0000-0002-0035-1455)
- Jong-Ho Lee (ORCID: https://orcid.org/0000-0002-8843-545X)
- Yuh‐Seog Jung (ORCID: https://orcid.org/0000-0002-9467-4916)
- Sung Yong Choi (ORCID: https://orcid.org/0000-0002-4865-5677)
- Wonyoung Choi (ORCID: https://orcid.org/0000-0002-5317-2055)
- Sun-Young Kong
Institutions
- National Cancer Center (US)
- Hematology\Oncology Clinic (US)
- The Korean Society of Pediatric Hematology-Oncology (KR)
- National Cancer Center (KR)
- Sacred Heart Hospital (US)
Publication Details
- Journal
- Cancer Research and Treatment
- Published
- 2025-11-04
- DOI
- https://doi.org/10.4143/crt.2025.1089
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00