Cholinergic basal forebrain degeneration is associated with central fatigue in Parkinson’s disease

This study provides initial neuroimaging evidence linking cholinergic basal forebrain structural integrity with central fatigue in Parkinson's disease. The consistent associations observed between fatigue severity and bilateral Ch4 morphology, supported by parallel GMD and GMV analyses, suggest a potential role for CBFB degeneration in PD-related fatigue. While further validation is needed, these findings contribute to the growing evidence supporting cholinergic involvement in non-motor symptoms and highlight Ch4 as a promising region for future investigations into fatigue mechanisms.