AIMing for survival: The impact of the free and total AIM concentration in septic patients
Total AIM concentration is a significant predictor of a 30-day survival in sepsis, supporting its potential use as a prognostic biomarker. Our findings also suggest that AIM may serve as a valuable prognostic biomarker and a potential target for immune-modulating therapies, including IgM-enriched intravenous immunoglobulins (IVIGs).
Authors
- Birte Dyck (ORCID: https://orcid.org/0000-0002-1013-0015)
- Björn Ellger
- Stefan Ehrentraut (ORCID: https://orcid.org/0000-0001-5747-6737)
- Dietrich Henzler (ORCID: https://orcid.org/0000-0001-5511-6885)
- Matthias Unterberg (ORCID: https://orcid.org/0000-0002-1500-1984)
- Tim Rahmel (ORCID: https://orcid.org/0000-0002-7039-6288)
- Lars Palmowski
- Christian Müller (ORCID: https://orcid.org/0000-0003-4700-0502)
- Nina Babel (ORCID: https://orcid.org/0000-0003-3673-712X)
- Katrin Marcus (ORCID: https://orcid.org/0000-0002-3313-8845)
- Lars Bergmann (ORCID: https://orcid.org/0000-0002-8603-8549)
- Björn Koos (ORCID: https://orcid.org/0000-0002-0544-4124)
- Andrea Witowski
- Katharina Rump (ORCID: https://orcid.org/0000-0003-2220-519X)
- Michael Adamzik (ORCID: https://orcid.org/0000-0002-7188-4873)
- Barbara Sitek
- Alexander von Busch
- Alexander Wolf (ORCID: https://orcid.org/0000-0001-8875-586X)
- Hartmuth Nowak (ORCID: https://orcid.org/0000-0002-6509-1463)
- Dominik Ziehe
- Martin Eisenacher (ORCID: https://orcid.org/0000-0003-2687-7444)
- Christian Putensen
- Alexander Zarbock
- Britta Westhus (ORCID: https://orcid.org/0009-0000-6298-690X)
- Ulrich Bosch dos Santos
Institutions
- University Hospital Bonn (DE)
- University Hospitals of the Ruhr-University of Bochum (DE)
- Klinikum Westfalen (Germany) (DE)
- Universitätsklinik Marien Hospital Herne (DE)
- Progress-Institut für Wirtschaftsforschung (DE)
- Biotest (Germany) (DE)
- Universitätsklinikum Knappschaftskrankenhaus Bochum (DE)
- Herford Hospital (DE)
- LWL-Universitätsklinikum Bochum (DE)
- Klinik für Schlafmedizin (CH)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1685119
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00