AIMing for survival: The impact of the free and total AIM concentration in septic patients

Total AIM concentration is a significant predictor of a 30-day survival in sepsis, supporting its potential use as a prognostic biomarker. Our findings also suggest that AIM may serve as a valuable prognostic biomarker and a potential target for immune-modulating therapies, including IgM-enriched intravenous immunoglobulins (IVIGs).

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Publication Details

Journal
Frontiers in Immunology
Published
2025-11-04
DOI
https://doi.org/10.3389/fimmu.2025.1685119
Primary Topic
Complement system in diseases
Type
article
Field-Weighted Citation Impact
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article

AIMing for survival: The impact of the free and total AIM concentration in septic patients

Birte Dyck, Björn Ellger, Stefan Ehrentraut, Dietrich Henzler et al.
Frontiers in Immunology
Complement system in diseases
article

AIMing for survival: The impact of the free and total AIM concentration in septic patients

Birte Dyck, Björn Ellger, Stefan Ehrentraut, Dietrich Henzler, Matthias Unterberg, Tim Rahmel, Lars Palmowski, Christian Müller, Nina Babel, Katrin Marcus, Lars Bergmann, Björn Koos, Andrea Witowski, Katharina Rump, Michael Adamzik, Barbara Sitek, Alexander von Busch, Alexander Wolf, Hartmuth Nowak, Dominik Ziehe, Martin Eisenacher, Christian Putensen, Alexander Zarbock, Britta Westhus, Ulrich Bosch dos Santos
article en

Abstract

Total AIM concentration is a significant predictor of a 30-day survival in sepsis, supporting its potential use as a prognostic biomarker. Our findings also suggest that AIM may serve as a valuable prognostic biomarker and a potential target for immune-modulating therapies, including IgM-enriched intravenous immunoglobulins (IVIGs).

Frontiers in ImmunologyVol. 16
University Hospital Bonn (DE), University Hospitals of the Ruhr-University of Bochum (DE), Klinikum Westfalen (Germany) (DE), Universitätsklinik Marien Hospital Herne (DE), Progress-Institut für Wirtschaftsforschung (DE), Biotest (Germany) (DE), Universitätsklinikum Knappschaftskrankenhaus Bochum (DE), Herford Hospital (DE), LWL-Universitätsklinikum Bochum (DE), Klinik für Schlafmedizin (CH), Ruhr University Bochum (DE)
Openalex Percentile: Top 66%
Complement system in diseases
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