The cerebrospinal fluid virome in people with HIV: links to neuroinflammation and cognition
This study provides the first comprehensive description of the CSF virome in PWH, revealing associations with neuroinflammation and cognition. These findings highlight the potential involvement of the CSF virome in brain health and inform about its composition, origin, and potential clinical implications in people with and without HIV.
Authors
- Vanessa Fini (ORCID: https://orcid.org/0000-0002-4489-8137)
- Andrea Calcagno (ORCID: https://orcid.org/0000-0003-2534-8815)
- Raha Maryam Dastgheyb (ORCID: https://orcid.org/0000-0002-4992-711X)
- Valeria Fox (ORCID: https://orcid.org/0000-0002-4552-8461)
- Annarita Granaglia
- Claudia Alteri (ORCID: https://orcid.org/0000-0003-4270-5079)
- Rossana Scutari (ORCID: https://orcid.org/0000-0001-8549-9645)
- Stefano Bonora
- Mattia Trunfio (ORCID: https://orcid.org/0000-0001-8663-719X)
- Carlo Federico Perno (ORCID: https://orcid.org/0000-0002-0825-5388)
- Elisa Vuaran
- Giovanni Di Perri
- Francesca Balbo
- Dora Tortarolo
Institutions
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Johns Hopkins University (US)
- University of Milan (IT)
- Johns Hopkins Medicine (US)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- University of California San Diego (US)
- Saint Camillus International University of Health and Medical Sciences (IT)
- Ospedale Amedeo di Savoia (IT)
- Azienda Ospedaliero Universitaria Maggiore della Carita (IT)
- Bambino Gesù Children's Hospital (IT)
- Azienda Ospedaliera Ospedale Maggiore (IT)
- Neurobehavioral Research (United States) (US)
- University of Turin (IT)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-11-04
- DOI
- https://doi.org/10.3389/fmicb.2025.1704392
- Citations
- 2
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.07
Funders
- Gilead Sciences
- University of California, San Diego
- National Institute of Mental Health