Ferritin nanoparticle vaccine displaying optimized spike protein confers broad protection against Omicron subvariants
The JN.1-4S1158 nanoparticle vaccine demonstrates broad-spectrum protective effects against Omicron subvariants and shows potential for further development. It also provides a basis for the development of a universal SARS-CoV-2 vaccine.
Authors
- S. Li
- Zhuo Ha (ORCID: https://orcid.org/0000-0002-0072-627X)
- Xiaoyang Yu (ORCID: https://orcid.org/0000-0003-1525-3169)
- Zhuoxin Li (ORCID: https://orcid.org/0000-0002-4687-4913)
- Wei Wang (ORCID: https://orcid.org/0000-0001-7788-1895)
- Huiyan Wang (ORCID: https://orcid.org/0000-0002-1068-5854)
- Sheng Feng (ORCID: https://orcid.org/0000-0003-0883-8345)
- H. Wang
Institutions
- Wenzhou University (CN)
- Changchun Institute of Optics, Fine Mechanics and Physics (CN)
- Changchun Institute of Applied Chemistry (CN)
- Jilin Medical University (CN)
- Wenzhou Institute of Industrial Science (CN)
- Institute of Special Animal and Plant Sciences (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-11-04
- DOI
- https://doi.org/10.3389/fcimb.2025.1676592
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- People's Government of Jilin Province
- National Key Research and Development Program of China