Characteristics of tertiary lymphoid structures in prostate cancer and the impact of neoadjuvant therapy on their formation and maturation
Our findings demonstrate that TLS serve as a favorable prognostic biomarker in prostate cancer. NHT enhances TLS formation, maturation, and immune cell infiltration, suggesting a synergistic role for androgen deprivation in shaping the tumor immune microenvironment. The improved anti-tumor response with combined anti-PD1 and ADT highlights the potential of immunotherapy-endocrine therapy combinations as a promising treatment strategy for PCa.
Authors
- Qiang Dong (ORCID: https://orcid.org/0009-0009-2730-0752)
- Xianding Wang (ORCID: https://orcid.org/0009-0006-8246-853X)
- Shengzhuo Liu (ORCID: https://orcid.org/0000-0001-8424-2549)
- Cheng-Jian Zhao
- Kai Ma (ORCID: https://orcid.org/0000-0002-0043-8710)
- Jing Zhou (ORCID: https://orcid.org/0000-0002-1537-0755)
- Xin Yan (ORCID: https://orcid.org/0000-0003-1147-8555)
- Yunfei Yu
- Xiaoyang Liu
- Li Yang (ORCID: https://orcid.org/0000-0001-8833-7473)
- Liangren Liu (ORCID: https://orcid.org/0000-0001-9748-4088)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1663396
- Citations
- 1
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Natural Science Foundation of Sichuan Province
- West China Hospital, Sichuan University