Gram-positive enhancer matrix delivering FVpE via M cell targeting elicit protective mucosal and adaptive immune responses against Helicobacter pylori infection
GEM-SAM-FVpE can effectively induce protective mucosal responses and adaptive immune responses against <i>H. pylori</i> infection, providing a new scheme for the development of oral vaccines against <i>H. pylori</i>.
Authors
- Le Guo
- Kunmei Liu (ORCID: https://orcid.org/0000-0002-1018-3336)
- Lin Xin (ORCID: https://orcid.org/0000-0002-4589-8593)
- Juan Chen (ORCID: https://orcid.org/0000-0002-7959-335X)
- Furui Zhang (ORCID: https://orcid.org/0000-0002-2601-4561)
- Zhen Zhang (ORCID: https://orcid.org/0000-0003-1361-408X)
- Hongpeng Liu (ORCID: https://orcid.org/0000-0002-6204-6085)
- Jiale Chen (ORCID: https://orcid.org/0000-0002-2980-2037)
- Linhan Ni
- Yaqin He (ORCID: https://orcid.org/0000-0001-6024-171X)
- Jing Wu
Institutions
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
- Shaanxi Provincial Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1697591
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Ningxia Province