Cellf-deception: human microglia clone 3 (HMC3) cells exhibit more astrocyte-like than microglia-like gene expression
These findings suggest that the HMC3 cell line is not a reliable human microglia model and that extreme caution should be taken when interpreting the results of studies using the HMC3 cell line.
Authors
- Kylee K. Rahm
- Melanie R. Moody (ORCID: https://orcid.org/0000-0003-0224-9881)
- Matthew H. Bailey (ORCID: https://orcid.org/0000-0003-4526-9727)
- Matthew H. Bailey (ORCID: https://orcid.org/0000-0003-4526-9727)
- Yulu Chang
- Brian Kinghorn
- Kaitlyn Strong
- Brian Kim (ORCID: https://orcid.org/0000-0002-0933-079X)
- Benjamin C. Stone
- A. J. Nitz (ORCID: https://orcid.org/0009-0004-6085-2835)
- Samantha N. Sleight
Institutions
- Brigham Young University (US)
Publication Details
- Journal
- Frontiers in Bioinformatics
- Published
- 2025-11-04
- DOI
- https://doi.org/10.3389/fbinf.2025.1681811
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Brigham Young University