Heterogeneous Hemostatic Disorder Associated with IgA Monoclonal Gammopathy: A Case Series

This case series highlights the diverse hemostatic manifestations of IgA monoclonal gammopathy, including AvWS, platelet dysfunction, and multiple clotting factor deficiencies. Despite having the same class of monoclonal protein, patients exhibited distinct clinical and laboratory findings, suggesting heterogeneous mechanisms of coagulation impairment. Awareness of these presentations in hematologic and immunologic practice is crucial for diagnosis and individualized management. Further research is needed to elucidate the molecular mechanisms underlying these hemostatic defects and develop targeted management strategies.