Design, Synthesis, and Biological Evaluation of Novel 7-Hydroxycoumarin- Based N-Hydroxyamides as Histone Deacetylase Inhibitors and Cytotoxic Agents
The research results suggest that some hydroxamic acids (5a and 7k) warrant further evaluation, and these results could serve as a basis for designing more potent HDAC inhibitors and antitumor agents.
Authors
- Tran Khac Vu (ORCID: https://orcid.org/0000-0003-1127-1597)
- Đỗ Thị Thảo (ORCID: https://orcid.org/0000-0002-8760-264X)
- Dinh Thi Phuong Anh
- Hai Pham‐The (ORCID: https://orcid.org/0000-0003-4531-7223)
- Duy Thanh Tran (ORCID: https://orcid.org/0000-0002-8076-7513)
- Luu Van Chinh
- Vu Xuan Thach
- Duong Quang Quy
Institutions
- Vietnam Academy of Science and Technology (VN)
- Hanoi University of Science and Technology (VN)
Publication Details
- Journal
- Medicinal Chemistry
- Published
- 2025-11-03
- DOI
- https://doi.org/10.2174/0115734064402162251011065534
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00