Diazaphospholene‐Catalyzed 1,6‐Conjugate Reduction of Para‐Quinone Methides
In the past 10 years, P ‐hydrido‐1,3,2‐diazaphospholenes (DAP‐Hs) have been demonstrated to be able to reduce carbonyls, imines, and enones. However, the 1,6‐conjugate reduction transformations catalyzed by DAP‐Hs have been rarely studied. Herein, we developed a DAP‐catalyzed 1,6‐conjugate reduction of p ‐QMs with DAP‐Br as the precatalyst. Furthermore, the dienone could also be well tolerated in this transformation.
Authors
- Zuolin Zhu (ORCID: https://orcid.org/0000-0002-4245-775X)
- Jie Wu (ORCID: https://orcid.org/0000-0002-0967-6360)
- Xiaoyu Zhou (ORCID: https://orcid.org/0000-0002-3552-3595)
- Gang Liu (ORCID: https://orcid.org/0000-0001-7269-9859)
- Wei Xiao (ORCID: https://orcid.org/0009-0000-8983-8755)
Institutions
- Chinese Academy of Sciences (CN)
- Jiangxi Science and Technology Normal University (CN)
- Shanghai Institute of Organic Chemistry (CN)
- Henan Normal University (CN)
- Taizhou University (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1002/adsc.70202
- Primary Topic
- Synthesis of Indole Derivatives
- Type
- article
- Field-Weighted Citation Impact
- 0.00