Congenital tuberculosis in preterm infants in a high-burden setting in southwest China: a single-center cross-sectional study
In this study, preterm infants with CTB frequently demonstrated non-specific clinical signs with a reversible pattern of inflammation, anemia, thrombocytopenia, and electrolyte disturbances that normalized after anti-TB therapy. These patterns, together with maternal TB risk or <i>in vitro</i> fertilization and embryo transfer history, may raise clinical suspicion and justify the early use of nucleic acid amplification testing, and generalizability outside this setting requires larger, controlled cohorts.
Authors
- Xuan Zhuang (ORCID: https://orcid.org/0000-0002-1919-9764)
- Caiyun Bian
- Wen Xu (ORCID: https://orcid.org/0000-0002-1308-9732)
- Mei Xiao (ORCID: https://orcid.org/0000-0002-5867-7044)
- Wenbin Dong (ORCID: https://orcid.org/0009-0004-0013-8437)
- Yan Shi (ORCID: https://orcid.org/0000-0003-0569-5350)
- Wei Xu (ORCID: https://orcid.org/0000-0003-4703-5983)
- Awai Rihei
Institutions
- Affiliated Hospital of Southwest Medical University (CN)
- Shanghai Liangyou (China) (CN)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-11-04
- DOI
- https://doi.org/10.3389/fped.2025.1657411
- Primary Topic
- Diagnosis and treatment of tuberculosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wu Jieping Medical Foundation