Can cell-free fetal DNA screening be utilized for the assessment of chromosomal abnormalities in fetuses with mildly increased nuchal translucency?
Using NIPS as a substitute for invasive prenatal diagnosis in cases of ImiNT should still be approached with caution. Couples must be ensured to understand the advantages and limitations of both methods. They should also be informed about the residual risk, ranging from 2.35 (1/43) to 3.63% (1/28), even after normal NIPS results. This understanding will help couples make informed decisions.
Authors
- Meiying Cai (ORCID: https://orcid.org/0000-0002-7431-2475)
- Xiaorui Xie (ORCID: https://orcid.org/0000-0002-9965-2791)
- Liangpu Xu (ORCID: https://orcid.org/0000-0001-8815-2735)
- Lin Zheng (ORCID: https://orcid.org/0000-0001-6178-1558)
- Wantong Zhao (ORCID: https://orcid.org/0009-0006-7298-0150)
- Xiaoqing Wu (ORCID: https://orcid.org/0000-0003-2605-2362)
- Linjuan Su (ORCID: https://orcid.org/0000-0001-7203-0821)
- Ying Li (ORCID: https://orcid.org/0000-0002-0882-5926)
- Hailong Huang (ORCID: https://orcid.org/0000-0001-5775-5082)
Institutions
- Fujian Medical University (CN)
- Fujian Women and Children Hospital (CN)
- Fujian Provincial Hospital (CN)
Publication Details
- Journal
- Archives of Gynecology and Obstetrics
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1007/s00404-025-08143-y
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fujian Medical University